Modulation of Neurovascular Coupling in the Retina: Effects of Oxygen and Diabetic Retinopathy A DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA By
نویسندگان
چکیده
.................................................................................................... iii List of tables ........................................................................................... viii List of figures............................................................................................ ix Chapter 1: Introduction.............................................................................1 Neuronal Control of Blood flow ............................................................ 2 Glial cells as intermediaries between neurons and vasculature ....... 4 K+ siphoning hypothesis of neurovascular coupling ......................... 5 BK channel hypothesis of neurovascular coupling............................ 6 The arachidonic acid metabolite hypothesis of neurovascular coupling .................................................................................................. 6 Neurovascular coupling in the retina ................................................... 8 Modulation of neurovascular coupling by NO................................... 10 Modulation of neurovascular coupling by O2 .................................... 11 Modulation of retinal neurovascular coupling by pathology ........... 14 Disruption of neurovascular coupling in diabetic retinopathy ........ 14 Chapter 2: Oxygen modulation of neurovascular coupling in the retina.........................................................................................................17 Introduction .......................................................................................... 17
منابع مشابه
Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-κB activation in vivo and in vitro
Objective(s): Naringin, an essential flavonoid, inhibits inflammatory response and oxidative stress in diabetes. However, whether naringin has beneficial effects on diabetic retinopathy (DR) remains unknown. Materials and Methods: Streptozotocin (STZ, 65 mg/kg) was intraperitoneally injected into male rats (8 weeks old weighting 200-250 g) to establish diabetic model, then naringin (20, 40 or 8...
متن کاملThe Intra-Ocular Pressure of Type 2 Diabetic Patients Comparison in Diabetic Retinopathy Grades
Objective: Retinopathy is a microvascular complication of diabetes in the retina. It is hypothesized the aqueous flow decrease in patients with retinopathy which effects the Intra-ocular pressure (IOP). The purpose of this study is to determine whether a significant correlation exists between IOP and diabetic retinopathy grades. Materials and Methods: Our study is analytic cross sectional. Abo...
متن کاملEffects of Laser Physical Parameters on Lesion Size in Retinal Photocoagulation Surgery: Clinical OCT and Experimental Study
Introduction: The aim of the present study was to determine burn intensity in retinal laser photocoagulation based on laser parameters; wavelength, power, beam size and pulse duration, using Optical Coherence Tomography (OCT), fundus camera, physical eye model and computer simulation in a clinical study.Materials and Methods: Participants were 10 adult patients between 50-80 years with prolifer...
متن کاملAssociation of CXCL12 and CXCR4 Genes Polymorphism with Proliferative Diabetic Retinopathy in Diabetic Patients
Introduction: Patients with diabetes are prone to develop complications related to the retina. So far, several genes have been reported in connection with the progression of retinopathy, and a group of these genes is genes involved in angiogenesis. CXCL12 and CXCR4 genes are among the most important genes in this path, which have been less studied and investigated. The aim of this study was to ...
متن کاملHuman Neurophysiological Mechanisms of Contextual Modulation in Primary Visual Cortex A DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY
........................................................................................................................................... ii Table of
متن کامل